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The smaller final step from 8mg to 12mg (a 50% increase rather than a 100% doubling) reflects the finding that GI tolerability improves at higher doses once the body has already adapted to substantial receptor activation

[DOI] [PubMed] [Google Scholar] 211.Asa E., Ahmadi R., Mahmoodi M., Mohammadniya A

However, it has also been shown that sympathetic neurons undergo lipid peroxidation following cleavage of the p75 neurotrophic factor receptor, causing degeneration and cell death (121)